SCHEMBL30445192

SCHEMBL30445192

CCc1nc2c(C(=O)O)cccc2o1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.46
IDO1 P14902 1/20 0.46
MAOA P21397 1/20 0.46
GAA P10253 1/20 0.43
TOP2A P11388 2/20 0.43
ALDH1A1 P00352 1/20 0.42
PARP1 P09874 1/20 0.40
PTGES O14684 1/20 0.40
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
MEN1 O00255 1/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CLCN2 P51788 1/20 0.38
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA3 P07451 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7721868 1.00 MAOB (0.46) MAOBIDO1MAOAGAATOP2A
SCHEMBL19298146 0.88 IDO1 (0.44) MAOBIDO1MAOATOP2AALDH1A1
SCHEMBL7589953 0.87 MAOB (0.48) MAOBIDO1MAOATOP2AALDH1A1
SCHEMBL7721972 0.84 TOP2A (0.55) GAATOP2AALDH1A1PTGESKDM4E
SCHEMBL4306060 0.82 LMNA (0.47) MAOBIDO1MAOATOP2AALDH1A1
SCHEMBL8910532 0.80 GAA (0.46) MAOBMAOAGAAALDH1A1KDM4E
SCHEMBL4304431 0.80 IDO1 (0.43) MAOBIDO1MAOATOP2AALDH1A1
SCHEMBL496431 0.79 MAOB (0.49) MAOBIDO1MAOATOP2AALDH1A1
SCHEMBL28467653 0.78 GABRA1 (0.42) GAAALDH1A1KDM4EHPGDNPC1
SCHEMBL4308379 0.78 MAOB (0.46) MAOBIDO1MAOATOP2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110678450-B Isoxazole derivatives as nuclear receptor agonists and uses thereof 日东制药株式会社 2023-06-20 CN claimed
CN-110678450-B Isoxazole derivatives as nuclear receptor agonists and uses thereof 日东制药株式会社 2023-06-20 CN disclosed