Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22206905 | 1.00 | ADRA2A (0.33) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL22206852 | 0.83 | PSEN1 (0.33) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL28415620 | 0.82 | CES2 (0.46) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL22206862 | 0.79 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL7147924 | 0.79 | ADRA2C (0.53) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL30446707 | 0.79 | ADRA2A (0.44) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL3199864 | 0.75 | ADRB2 (0.31) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL22206886 | 0.74 | PSEN1 (0.34) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL22206836 | 0.74 | PSEN1 (0.34) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL30447120 | 0.74 | PSEN1 (0.34) | ADRA2AADRA2BADRA2CADRA1AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111434671-B | Liver-specific AMPK agonist and preparation method and application thereof | 凯思凯迪（上海）医药科技有限公司 | 2023-07-11 | — | — | CN | disclosed |