Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | FOS | P01100 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036388 | 0.87 | ALDH1A1 (0.34) | CA2PTGS2HTR2AALOX15ALOX12 | |
| SCHEMBL13347308 | 0.86 | PRKDC (0.39) | LMNAKDM4E | |
| SCHEMBL3043068 | 0.83 | CA2 (0.35) | CA2PTGS2HTR2AALOX15ALOX12 | |
| SCHEMBL1613836 | 0.82 | MAPT (0.37) | CA2PTGS2HTR2AFOSTTR | |
| SCHEMBL3039601 | 0.80 | LMNA (0.36) | LMNACA2PTGS2ALOX15ALOX12 | |
| SCHEMBL1023208 | 0.77 | PTGS2 (0.41) | CA2PTGS2HTR2AHTR2CHTR2B | |
| Ethylene SCHEMBL5783390 | 0.75 | ALDH1A1 (0.40) | LMNAKDM4E | |
| SCHEMBL3037185 | 0.74 | PTGS2 (0.40) | CA2PTGS2HTR2AHTR2CHTR2B | |
| SCHEMBL8429647 | 0.72 | PTGS2 (0.64) | CA2PTGS2HTR2AHTR2CHTR2B | |
| SCHEMBL30041126 | 0.69 | CA2 (0.43) | CA2PTGS2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101827843-A | Pyrazole fused ring derivatives and process for preparation thereof | EISAI R&D MAN CO LTD | 2010-09-08 | — | — | CN | disclosed |
| US-20100217001-A1 | METHOD FOR PRODUCING PYRAZOLE FUSED RING DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| US-20100217001-A1 | METHOD FOR PRODUCING PYRAZOLE FUSED RING DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| US-20100217001-A1 | METHOD FOR PRODUCING PYRAZOLE FUSED RING DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| EP-2202233-A1 | METHOD FOR PRODUCING PYRAZOLE FUSED RING DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2010-06-30 | — | — | EP | disclosed |
| EP-2202233-A1 | METHOD FOR PRODUCING PYRAZOLE FUSED RING DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2010-06-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217001-A1 | METHOD FOR PRODUCING PYRAZOLE FUSED RING DERIVATIVE | CYP3A4, CYP4B1, CYP51A1 | LMNA 4426/4885CA2 4183/4885PTGS2 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.