Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447826 | 0.80 | KIT (0.52) | GPR119 | |
| SCHEMBL24330062 | 0.76 | CNR1 (0.45) | GPR119MMP13LMNATP53MAPT | |
| SCHEMBL29468194 | 0.75 | GPR119 (0.45) | GPR119MMP13TP53KMT2ATDP1 | |
| SCHEMBL26911683 | 0.75 | GPR119 (0.45) | GPR119MMP13TP53KMT2ATDP1 | |
| SCHEMBL7099217 | 0.75 | GPR119 (0.51) | GPR119MMP13LMNATP53MAPT | |
| SCHEMBL24330045 | 0.73 | GPR119 (0.45) | GPR119MMP13 | |
| SCHEMBL16610232 | 0.73 | SCN9A (0.44) | GPR119MMP13EPHX2 | |
| SCHEMBL1570643 | 0.72 | HTR6 (0.58) | — | |
| SCHEMBL24331519 | 0.72 | TP53 (0.44) | GPR119MMP13LMNATP53MAPT | |
| SCHEMBL10265584 | 0.71 | GPR119 (0.57) | GPR119MMP13TP53EPHX2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133229-A2 | COMPOUNDS AND METHODS FOR MODULATING SPLICING | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |
| EP-4178963-A1 | 5-[5-(PIPERIDIN-4-YL)THIENO[3,2-C]PYRAZOL-2-YL]INDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Remix Therapeutics Inc. (US) | 2023-05-17 | — | — | EP | disclosed |