Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 9/20 | 0.41 |
| ▸ | GRM5 | P41594 | 8/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30447476 | 0.80 | GPR119 (0.45) | GPR119 | |
| SCHEMBL1417900 | 0.73 | ESR2 (0.45) | HTR6GPR119 | |
| SCHEMBL28668463 | 0.73 | PDK4 (0.54) | KITHTR6GPR119PDK4GRM1 | |
| SCHEMBL8912847 | 0.72 | NAMPT (0.63) | KITHTR6GPR119PDK4GRM1 | |
| SCHEMBL18080760 | 0.72 | HTR6 (0.64) | KITHTR6GPR119PDK4GRM1 | |
| SCHEMBL22777065 | 0.71 | HTR6 (0.60) | KITHTR6GPR119PDK4GRM1 | |
| SCHEMBL15555500 | 0.71 | HTR6 (0.49) | KITHTR6GPR119PDK4GRM1 | |
| SCHEMBL31189181 | 0.71 | KIT (0.47) | KITGPR119PDK4GRM1GRM5 | |
| SCHEMBL31189189 | 0.71 | KIT (0.47) | KITGPR119PDK4GRM1GRM5 | |
| SCHEMBL22324776 | 0.70 | HTR6 (0.55) | KITHTR6GPR119PDK4GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133229-A2 | COMPOUNDS AND METHODS FOR MODULATING SPLICING | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |
| EP-4178963-A1 | 5-[5-(PIPERIDIN-4-YL)THIENO[3,2-C]PYRAZOL-2-YL]INDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Remix Therapeutics Inc. (US) | 2023-05-17 | — | — | EP | disclosed |