SCHEMBL30456538

SCHEMBL30456538

CN(CC(F)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)C(=O)OCc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.38
CHRNB4 P30926 1/20 0.38
CHRNA3 P32297 1/20 0.38
CHRNA4 P43681 1/20 0.38
ITGB3 P05106 2/20 0.35
ITGA2B P08514 2/20 0.35
ABCB1 P08183 1/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
CYP3A4 P08684 1/20 0.34
HTT P42858 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34
ATM Q13315 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
CACNA1H O95180 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4316109 0.88 CHRNB2 (0.39) CHRNB2CHRNB4CHRNA3CHRNA4ITGB3
SCHEMBL25364954 0.86 HTT (0.37) CHRNB2CHRNB4CHRNA3CHRNA4ALDH1A1
SCHEMBL5724513 0.83 ALDH1A1 (0.40) CHRNB2CHRNB4CHRNA3CHRNA4ITGB3
SCHEMBL23455720 0.83 ITGB3 (0.44) CHRNB2CHRNB4CHRNA3CHRNA4ITGB3
SCHEMBL23455719 0.83 ITGB3 (0.44) CHRNB2CHRNB4CHRNA3CHRNA4ITGB3
SCHEMBL30456499 0.80 SYK (0.44) MAPTSMN1; SMN2HTTATM
SCHEMBL4323360 0.80 ALDH1A1 (0.37) CHRNB2CHRNB4CHRNA3CHRNA4ITGB3
SCHEMBL25363634 0.78 CHRNB2 (0.44) CHRNB2CHRNB4CHRNA3CHRNA4ABCB1
SCHEMBL4335741 0.78 ITGB3 (0.35) CHRNB2CHRNB4CHRNA3CHRNA4ITGB3
SCHEMBL14296506 0.78 ALDH1A1 (0.41) ALDH1A1HPGDSMN1; SMN2CYP3A4HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023116761-A1 PYRIMIDINE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE 英矽智能科技知识产权有限公司 2023-06-29 WO disclosed