Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | MC4R | P32245 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23292322 | 0.82 | NOS2 (0.52) | NOS2MAP4K4NOS1NOS3POLB | |
| SCHEMBL31634686 | 0.81 | USP30 (0.48) | MAPT | |
| SCHEMBL30948976 | 0.81 | USP30 (0.48) | MAPT | |
| SCHEMBL31421677 | 0.81 | USP30 (0.48) | MAPT | |
| SCHEMBL25225248 | 0.81 | MC4R (0.46) | NOS2MAP4K4MC4RKCNH2LMNA | |
| SCHEMBL23292432 | 0.79 | CCNK (0.51) | NOS2MAP4K4NOS1NOS3POLB | |
| SCHEMBL30457945 | 0.78 | HDAC4 (0.47) | MAP4K4MC4RKCNH2 | |
| SCHEMBL30458624 | 0.78 | MC4R (0.60) | NOS2MAP4K4NOS1NOS3MC4R | |
| SCHEMBL23292267 | 0.77 | CYP3A4 (0.55) | NOS2NOS1NOS3 | |
| SCHEMBL18613893 | 0.76 | KDM4E (0.49) | NOS2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444708-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | Pfizer Inc. (US) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023105387-A1 | MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | PFIZER INC. (US) | 2023-06-15 | — | — | WO | disclosed |