Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.34 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5287417 | 0.83 | DGAT1 (0.45) | SMN1; SMN2DRD2DRD3HTR1D | |
| SCHEMBL1807301 | 0.80 | DRD2 (0.39) | DRD2DRD3HTR1DPRNPCHRM1 | |
| SCHEMBL630002 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2PRNPCA1CA2 | |
| SCHEMBL18248703 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2DRD2DRD3HTR1DPRNP | |
| SCHEMBL14061880 | 0.78 | DGAT1 (0.56) | SMN1; SMN2DRD2DRD3HTR1D | |
| SCHEMBL14061941 | 0.78 | DGAT1 (0.41) | SMN1; SMN2DRD2DRD3HTR1D | |
| SCHEMBL14137116 | 0.77 | BACE1 (0.38) | SMN1; SMN2DRD2DRD3HTR1DPRNP | |
| SCHEMBL4157926 | 0.77 | MAOB (0.57) | DRD2DRD3HTR1DMAOBGRM5 | |
| SCHEMBL9588225 | 0.76 | TDP2 (0.48) | SMN1; SMN2HTR2CCYP24A1 | |
| SCHEMBL14137097 | 0.75 | DGAT1 (0.49) | SMN1; SMN2DRD2DRD3HTR1DBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222363-A1 | Bicyclic Derivatives as P38 Inhibitors | PALAU PHARMA, S.A. (ES) | 2010-09-02 | — | — | US | disclosed |
| US-20090286775-A1 | Bicyclic Derivatives as P38 Kinase Inhibitors | PALAU PHARMA, S.A. (ES) | 2009-11-19 | — | — | US | disclosed |
| WO-2007000337-A1 | BICYCLIC DERIVATIVES AS P38 KINASE INHIBITORS | PALAU PHARMA, S.A. (ES) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222363-A1 | Bicyclic Derivatives as P38 Inhibitors | MAPK1, MAPKAPK2, MAPK7 | SMN1; SMN2 3351/4885DRD2 4522/4885DRD3 4055/4885 |
| US-20090286775-A1 | Bicyclic Derivatives as P38 Kinase Inhibitors | MAPK1, MAPKAPK2, MAPKAPK3 | SMN1; SMN2 3588/4885DRD2 4472/4885DRD3 4019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.