Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 10/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 10/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 10/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 10/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 10/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 10/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25331903 | 1.00 | NR4A2 (0.37) | NR4A2MAP2K1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL25331800 | 0.87 | MAP2K1 (0.40) | NR4A2MAP2K1PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL25331893 | 0.79 | PRKAG1 (0.50) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL25999701 | 0.71 | GABRA1 (0.55) | — | |
| SCHEMBL31748637 | 0.69 | GPR84 (0.31) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL31386176 | 0.69 | GPR84 (0.35) | — | |
| SCHEMBL22438703 | 0.68 | GPR84 (0.45) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL25332491 | 0.67 | NR4A2 (0.44) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL30469053 | 0.67 | NR4A2 (0.44) | NR4A2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL15805616 | 0.65 | MAP2K1 (0.51) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469436-A1 | AMPK AGONISTS AND METHODS OF USE THEREOF | Evvia Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023147312-A1 | AMPK AGONISTS AND METHODS OF USE THEREOF | EVVIA THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |