Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1966251 | 0.93 | HTR2C (0.49) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL302774 | 0.78 | HTR2C (0.58) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL304038 | 0.78 | NPC1 (0.42) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL306481 | 0.76 | PARP1 (0.42) | CNR2ALDH1A1HTTLMNAMEN1 | |
| SCHEMBL303627 | 0.75 | HTR2C (0.39) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL1968022 | 0.74 | KMT2A (0.48) | HTR2CHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL3377134 | 0.73 | KMT2A (0.42) | CNR2ALDH1A1HTTLMNAEP300 | |
| SCHEMBL3275899 | 0.71 | HTR2C (0.49) | CNR2HTR2CHTR1AHTR2AHTR7 | |
| SCHEMBL3378121 | 0.71 | MAPT (0.46) | HTR2CHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL3377040 | 0.70 | LMNA (0.48) | HTR2CHTR1AHTR2AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500835-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | claimed |
| EP-2334637-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-06-22 | — | — | EP | disclosed |