Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 3/20 | 0.45 |
| ▸ | METAP2 | P50579 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.40 |
| ▸ | WNT3A | P56704 | 5/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL616074 | 1.00 | AXL (0.46) | AXLNOS1METAP2DYRK1ANPC1 | |
| SCHEMBL22446038 | 0.82 | CASP6 (0.54) | AXLNOS1METAP2DYRK1ANPC1 | |
| SCHEMBL617024 | 0.81 | AXL (0.53) | AXLNOS1METAP2DYRK1ANPC1 | |
| SCHEMBL18554980 | 0.77 | AXL (0.56) | AXLNOS1METAP2DYRK1ANPC1 | |
| SCHEMBL30286390 | 0.77 | AXL (0.56) | AXLNOS1METAP2DYRK1ANPC1 | |
| SCHEMBL2926007 | 0.76 | PTPN1 (0.51) | NOS1METAP2DYRK1ACTNNB1WNT3A | |
| SCHEMBL616794 | 0.76 | NOS1 (0.44) | NOS1CTNNB1WNT3ACHEK1MEN1 | |
| SCHEMBL15059952 | 0.73 | CTNNB1 (0.67) | NOS1METAP2DYRK1ANPC1RAB9A | |
| SCHEMBL616185 | 0.73 | AXL (0.51) | AXLNOS1METAP2DYRK1ANPC1 | |
| SCHEMBL26322070 | 0.72 | ALDH1A1 (0.46) | AXLNPC1RAB9ACTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107973809-B | Macrocyclic compounds as factor XIA inhibitors | 百时美施贵宝公司 | 2023-06-30 | — | — | CN | disclosed |