Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.62 |
| ▸ | LTK | P29376 | 1/20 | 0.62 |
| ▸ | MST1R | Q04912 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAP3K9 | P80192 | 2/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3047923 | 0.83 | CDK5 (0.62) | CDK5DYRK1ACLK4LTKMST1R | |
| SCHEMBL3039949 | 0.76 | MAP3K9 (0.50) | CDK5DYRK1ACLK4MAP3K9MAP3K11 | |
| SCHEMBL18170811 | 0.73 | LTK (0.47) | CDK5DYRK1ACLK4LTKMST1R | |
| SCHEMBL3034051 | 0.71 | TDP2 (0.37) | CDK5DYRK1ACLK4MAP3K9MAP3K11 | |
| SCHEMBL3835838 | 0.69 | TDP2 (0.42) | PARP1MAP3K9MAP3K11CHEK1WEE1 | |
| SCHEMBL3048539 | 0.68 | CLK1 (0.43) | CDK5DYRK1ACLK4PARP1MAP3K9 | |
| SCHEMBL3039244 | 0.68 | PARP1 (0.36) | CDK5DYRK1ACLK4PARP1MAP3K9 | |
| SCHEMBL3046642 | 0.68 | MAP3K9 (0.36) | CDK5DYRK1ACLK4PARP1MAP3K9 | |
| SCHEMBL3040957 | 0.68 | ROCK2 (0.37) | CDK5DYRK1ACLK4PARP1MAP3K9 | |
| SCHEMBL27720804 | 0.68 | LTK (0.41) | CDK5DYRK1ACLK4LTKMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745641-B2 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-02-26 | — | — | US | disclosed |
| EP-1880993-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054407-A1 | Nitrogen-containing heterocyclic compound | NR4A1, NR5A2, PRMT8 | CDK5 760/4885DYRK1A 3145/4885CLK4 943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.