SCHEMBL30485249

SCHEMBL30485249

Clc1nc2cccc(CBr)n2n1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NUDT1 P36639 2/20 0.33
AHR P35869 1/20 0.33
PDE10A Q9Y233 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3303036 0.84 AHR (0.37) NUDT1AHRPDE10A
SCHEMBL30485242 0.72 CYP11B2 (0.45) PDE10A
SCHEMBL12078961 0.66 AHR (0.34) AHRPDE10A
SCHEMBL25074680 0.64 AHR (0.39) NUDT1AHRPDE10A
SCHEMBL544044 0.61 EGLN2 (0.48) NUDT1PDE10A
SCHEMBL18366670 0.61 PDE10A (0.42) NUDT1PDE10A
SCHEMBL13390528 0.61 NUDT1 (0.51) NUDT1PDE10A
SCHEMBL5300653 0.59 JAK2 (0.50) NUDT1AHRPDE10A
SCHEMBL25392809 0.59 RAB9A (0.37) PDE10A
SCHEMBL2252947 0.59 NUDT1 (0.49) NUDT1PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118215664-B Substituted triazoloheteroaryl compounds as USP1 inhibitors and uses thereof 上海瑛派药业有限公司 2025-05-06 CN disclosed
EP-4419522-A1 SUBSTITUTED TRIAZOLOHETEROARYL COMPOUNDS AS USP1 INHIBITORS AND THE USE THEREOF Impact Therapeutics (Shanghai), Inc (CN) 2024-08-28 EP disclosed
CN-118215664-A Substituted triazoloheteroaryl compounds as USP1 inhibitors and uses thereof 上海瑛派药业有限公司 2024-06-18 CN disclosed
WO-2023066299-A1 SUBSTITUTED TRIAZOLOHETEROARYL COMPOUNDS AS USP1 INHIBITORS AND THE USE THEREOF IMPACT THERAPEUTICS (SHANGHAI) , INC (CN) 2023-04-27 WO disclosed