Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 7/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.39 |
| ▸ | ITGB6 | P18564 | 2/20 | 0.35 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158346 | 0.93 | ITGAV (0.45) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL20141629 | 0.92 | ITGB3 (0.41) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL30487498 | 0.82 | ITGAV (0.54) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL21317519 | 0.79 | STS (0.41) | ITGB3ITGA2BNPC1RAB9AKIT | |
| SCHEMBL20158348 | 0.76 | ITGAV (0.65) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL20142679 | 0.74 | ITGB3 (0.64) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL27406006 | 0.74 | MPO (0.38) | ITGAVITGB6NPC1RAB9A | |
| SCHEMBL27003184 | 0.73 | NPC1 (0.36) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL28709236 | 0.73 | ITGB3 (0.37) | ITGAVITGB3ITGB5ITGB6ITGB8 | |
| SCHEMBL20158349 | 0.72 | STS (0.56) | NPC1RAB9ASTSMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11639353-B2 | Cyclobutanes- and azetidine-containing mono and spirocyclic compounds as αV integrin inhibitors | ITGB1, ITGB2, ITGA1 | ITGAV 4/4885ITGB3 6/4885ITGA2B 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.