SCHEMBL30488207

SCHEMBL30488207

Cc1ccc(COc2ccc3c(c2)CCC3=O)cc1C(F)(F)F

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAOB P27338 17/20 0.63
MAOA P21397 15/20 0.63
SRD5A1 P18405 1/20 0.46
ADAMTS4 O75173 1/20 0.46
HRH3 Q9Y5N1 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25276866 1.00 MAOB (0.63) MAOBMAOASRD5A1ADAMTS4HRH3
SCHEMBL30488247 0.84 MAOB (0.57) MAOBMAOAADAMTS4
SCHEMBL25228663 0.84 MAOB (0.57) MAOBMAOAADAMTS4
SCHEMBL25277729 0.82 MAOB (0.60) MAOBMAOAHRH3
SCHEMBL30488246 0.82 MAOB (0.60) MAOBMAOAHRH3
SCHEMBL5638876 0.82 MAOB (0.86) MAOBMAOASRD5A1
SCHEMBL25226722 0.79 MAOB (0.69) MAOBMAOA
SCHEMBL30488283 0.79 MAOB (0.69) MAOBMAOA
SCHEMBL25224654 0.78 MAOB (0.64) MAOBMAOAHRH3
SCHEMBL30488307 0.78 MAOB (0.64) MAOBMAOAHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4444697-A1 CARBOXYLIC ACID CONTAINING INDANYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CELGENE CORPORATION (US) 2024-10-16 EP disclosed
CN-118632834-A Indanyl compounds containing carboxylic acids for the treatment of neurodegenerative diseases 细胞基因公司 2024-09-10 CN disclosed
WO-2023107563-A1 CARBOXYLIC ACID CONTAINING INDANYL COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES CELGENE CORPORATION (US) 2023-06-15 WO disclosed