Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.37 |
| ▸ | RELA | Q04206 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21066163 | 0.81 | GABRG2 (0.46) | HPGDALDH1A1KMT2ASMARCA2SMARCA4 | |
| SCHEMBL10535514 | 0.81 | CYP2A6 (0.48) | HPGDHSD17B10ALDH1A1NPC1RAB9A | |
| SCHEMBL5114621 | 0.75 | GABRG2 (0.61) | HPGDALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL30072473 | 0.75 | GABRG2 (0.61) | HPGDALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL5918300 | 0.75 | PDGFRB (0.50) | HPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3626709 | 0.73 | RORB (0.49) | HPGDHSD17B10ALDH1A1BCL2L1KMT2A | |
| SCHEMBL27779502 | 0.73 | HPGD (0.47) | HPGDHSD17B10ALDH1A1BCL2L1KMT2A | |
| SCHEMBL29499205 | 0.72 | HPGD (0.56) | HPGDHSD17B10ALDH1A1BCL2L1KMT2A | |
| SCHEMBL25220858 | 0.72 | ESR1 (0.44) | BCL2L1KMT2AESR2MEN1NPC1 | |
| SCHEMBL27586879 | 0.72 | ALDH1A1 (0.50) | HPGDHSD17B10ALDH1A1BCL2L1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116529250-A | 6-substituted pyridazine compounds as SMARCA2 and/or SMARCA4 degrading agents | 奥里吉恩肿瘤学有限公司 | 2023-08-01 | — | — | CN | disclosed |