Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.37 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | CHUK | O15111 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309803 | 1.00 | TGFBR1 (0.37) | TGFBR1IKBKBCHUKNPC1RAB9A | |
| SCHEMBL30499652 | 0.77 | CNR1 (0.42) | CCNT1CDK9 | |
| SCHEMBL25311741 | 0.77 | CNR1 (0.42) | CCNT1CDK9 | |
| SCHEMBL25130926 | 0.76 | TGFBR1 (0.46) | TGFBR1IKBKBCHUKNPC1RAB9A | |
| SCHEMBL25309959 | 0.71 | LMNA (0.41) | TGFBR1CYP3A4 | |
| SCHEMBL30499631 | 0.71 | LMNA (0.41) | TGFBR1CYP3A4 | |
| SCHEMBL14500600 | 0.69 | CDK9 (0.46) | CCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL5661887 | 0.68 | CDK9 (0.46) | CCNT1CDK9 | |
| SCHEMBL31464360 | 0.67 | RIPK2 (0.47) | TGFBR1 | |
| SCHEMBL5005669 | 0.65 | RIPK2 (0.41) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4463448-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-11-20 | — | — | EP | disclosed |
| WO-2023135107-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-07-20 | — | — | WO | disclosed |