Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 7/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 7/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25311741 | 1.00 | CNR1 (0.42) | CNR1GRM5GRM1PDE10ADYRK2 | |
| SCHEMBL25309653 | 0.80 | GRM1 (0.49) | CNR1GRM5GRM1CDK9CCNT1 | |
| SCHEMBL31083662 | 0.80 | GRM1 (0.49) | CNR1GRM5GRM1CDK9CCNT1 | |
| SCHEMBL30499641 | 0.79 | WNT3A (0.39) | CNR1GRM5GRM1MKNK1CDK9 | |
| SCHEMBL25262809 | 0.79 | WNT3A (0.39) | CNR1GRM5GRM1MKNK1CDK9 | |
| SCHEMBL25309803 | 0.77 | TGFBR1 (0.37) | CDK9CCNT1 | |
| SCHEMBL30499653 | 0.77 | TGFBR1 (0.37) | CDK9CCNT1 | |
| SCHEMBL25869192 | 0.76 | WNT3A (0.37) | CNR1GRM5GRM1PDE10AMKNK1 | |
| SCHEMBL5661540 | 0.74 | CDK9 (0.56) | CNR1PDE10AKEAP1NFE2L2CDK9 | |
| SCHEMBL25307609 | 0.72 | LMNA (0.40) | CDK9CCNT1KITTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4463448-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-11-20 | — | — | EP | disclosed |
| CN-118541362-A | Pyridazinylamino derivatives as ALK5 inhibitors | 奇斯药制品公司 | 2024-08-23 | — | — | CN | disclosed |
| WO-2023135107-A1 | PYRIDAZINYL AMINO DERIVATIVES AS ALK5 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2023-07-20 | — | — | WO | disclosed |