Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 10/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 9/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 9/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 9/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 9/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29042113 | 0.87 | BMPR1B (0.48) | TGFBR1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL30508283 | 0.84 | BMPR1B (0.69) | TGFBR1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL30508345 | 0.75 | BMPR1B (0.59) | TGFBR1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL30508265 | 0.74 | AXL (0.58) | TGFBR1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL29042029 | 0.74 | AXL (0.58) | TGFBR1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL20897468 | 0.74 | ALDH1A1 (0.52) | USP2ALDH1A1CYP1A2CYP3A4HSD17B10 | |
| SCHEMBL3713695 | 0.74 | AXL (0.59) | TBK1IKBKEFYNALDH1A1HSD17B10 | |
| SCHEMBL29152375 | 0.72 | BMPR1B (0.64) | TGFBR1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL30508414 | 0.72 | BMPR1B (0.64) | TGFBR1BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL24532876 | 0.72 | MAPT (0.41) | ACVR1USP2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |