Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27901735 | 0.75 | KDM4E (0.48) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL9727230 | 0.75 | ERBB2 (0.46) | KDM4ECYP1A2POLBNPC1RAB9A | |
| SCHEMBL25428804 | 0.74 | TGFBR1 (0.40) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL25425525 | 0.74 | BTK (0.41) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL3978747 | 0.74 | KDM4E (0.46) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL18005957 | 0.73 | LRRK2 (0.42) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL2791425 | 0.71 | TGFBR1 (0.53) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL7964309 | 0.69 | KDM4E (0.52) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL7964313 | 0.69 | KDM4E (0.50) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL1834558 | 0.69 | PIN1 (0.53) | KDM4ELMNAMETAP1CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466258-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-11-27 | — | — | EP | disclosed |
| WO-2023139085-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |