Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25317913 | 1.00 | L3MBTL1 (0.39) | L3MBTL1CHRNB2CHRNA4ACACBKDM4E | |
| SCHEMBL13316482 | 0.95 | CHRNB2 (0.41) | L3MBTL1CHRNB2CHRNA4ACACBHTR2C | |
| SCHEMBL13316483 | 0.86 | CHRNB2 (0.40) | L3MBTL1CHRNB2CHRNA4ACACBKDM4E | |
| SCHEMBL25318049 | 0.79 | NCF1 (0.41) | — | |
| SCHEMBL6939611 | 0.78 | CHRNB2 (0.42) | CHRNB2CHRNA4KDM4ERECQLALDH1A1 | |
| SCHEMBL6936975 | 0.77 | NPC1 (0.48) | CHRNB2CHRNA4ACACBRECQLPOLB | |
| SCHEMBL3510010 | 0.75 | CHRNB2 (0.40) | CHRNB2CHRNA4RECQLLMNAALDH1A1 | |
| SCHEMBL6937171 | 0.75 | SOAT1 (0.44) | CHRNB2CHRNA4RECQL | |
| SCHEMBL19624156 | 0.74 | LMNA (0.41) | ACACBRECQLLMNAALDH1A1 | |
| SCHEMBL6940093 | 0.74 | CHRNB2 (0.42) | CHRNB2CHRNA4RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466258-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-11-27 | — | — | EP | disclosed |
| WO-2023139085-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |