Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3051832 | 0.89 | CHRNA7 (0.53) | TNIKCHRNA7GPR84MEN1KMT2A | |
| SCHEMBL3064135 | 0.87 | REV1 (0.56) | CHRNA7GPR84MEN1KMT2A | |
| SCHEMBL3057161 | 0.85 | MAPK1 (0.55) | CHRNA7GPR84MEN1KMT2A | |
| SCHEMBL3052820 | 0.85 | ROCK2 (0.55) | ROCK2TNIKROCK1ACHEMEN1 | |
| SCHEMBL3051083 | 0.82 | HTR2A (0.54) | CHRNA7GPR84 | |
| SCHEMBL31134765 | 0.82 | GRM5 (0.60) | ACHEGPR84MEN1KMT2AABCB1 | |
| SCHEMBL3041941 | 0.81 | CHRNA7 (0.53) | CHRNA7GPR84MEN1KMT2A | |
| SCHEMBL24617036 | 0.78 | ROCK2 (0.61) | ROCK2TNIKROCK1 | |
| SCHEMBL29779067 | 0.78 | ROCK2 (0.61) | ROCK2TNIKROCK1 | |
| SCHEMBL3049994 | 0.78 | MEN1 (0.48) | CHRNA7GPR84MEN1KMT2AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | claimed |
| US-8394825-B2 | Compound | STERIX LIMITED (GB) | 2013-03-12 | — | — | US | disclosed |
| US-20100222299-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222299-A1 | COMPOUND | MKI67, VHL, MYC | ROCK2 307/4885TNIK 1057/4885ROCK1 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.