SCHEMBL30512968

SCHEMBL30512968

Cc1ccc(Cn2[nH]c3cc(Cl)ccc3c2=O)cc1C

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 1/20 0.44
GRIN3B O60391 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2A Q12879 1/20 0.44
GRIN2B Q13224 1/20 0.44
GRIN2C Q14957 1/20 0.44
GRIN3A Q8TCU5 1/20 0.44
CCR2 P41597 1/20 0.43
TP53 P04637 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9646339 0.82 ALOX5 (0.51) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL25409456 0.81 KMT2A (0.48) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL18149341 0.72 ALOX5 (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL25410748 0.72 CA9 (0.49)
SCHEMBL9646320 0.71 ALOX5 (0.51)
SCHEMBL25410120 0.71 CA9 (0.44) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL11445937 0.67 ALDH1A1 (0.41) CCR2TP53
SCHEMBL11611826 0.67 APAF1 (0.36) TP53
SCHEMBL9645947 0.67 ALOX5 (0.50) SMN1; SMN2
SCHEMBL11613060 0.67 ALDH1A1 (0.41) CCR2TP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023138612-A1 HETEROCYCLIC COMPOUNDS USEFUL AS HPK1 INHIBITORS SILEXON AI TECHNOLOGY CO., LTD. (CN) 2023-07-27 WO disclosed