Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK3 | P49761 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | DYRK4 | Q9NR20 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 3/20 | 0.41 |
| ▸ | TEK | Q02763 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28639993 | 1.00 | SYK (0.48) | SYKKDRPLK1PTPN11DYRK3 | |
| SCHEMBL30513611 | 0.91 | PTPN11 (0.46) | SYKKDRPLK1PTPN11MAOA | |
| SCHEMBL28632683 | 0.91 | PTPN11 (0.46) | SYKKDRPLK1PTPN11MAOA | |
| SCHEMBL28651320 | 0.80 | PTPN11 (0.41) | PTPN11GSK3BMAOAMAOBABCB1 | |
| SCHEMBL30513609 | 0.80 | PTPN11 (0.41) | PTPN11GSK3BMAOAMAOBABCB1 | |
| SCHEMBL28644056 | 0.80 | PTPN11 (0.48) | PTPN11GSK3BMAOAMAOBMAP3K8 | |
| SCHEMBL4597033 | 0.79 | KDR (0.52) | SYKKDRPLK1DYRK3CLK2 | |
| SCHEMBL28637102 | 0.78 | MAOA (0.63) | GSK3BCLK4MAOAMAOBABCB1 | |
| SCHEMBL30513601 | 0.78 | MAPT (0.56) | PTPN11CLK2GSK3BDYRK1ACLK4 | |
| SCHEMBL28641831 | 0.78 | MAPT (0.56) | PTPN11CLK2GSK3BDYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759549-B | 3-substituted amino-4- ((substituted pyridinyl) amino) cyclobut-3-ene-1, 2-dione compounds | 中国医学科学院药物研究所 | 2023-07-28 | — | — | CN | disclosed |