Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.82 |
| ▸ | NPC1 | O15118 | 11/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.70 |
| ▸ | MEN1 | O00255 | 7/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | SCD | O00767 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4919731 | 0.90 | RAB9A (1.00) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL31050 | 0.89 | HSD17B1 (0.68) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL30919 | 0.87 | RAB9A (0.72) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL31005 | 0.85 | RAB9A (0.83) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL30847 | 0.85 | RAB9A (0.75) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL2486652 | 0.83 | RAB9A (0.75) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL4918858 | 0.83 | RAB9A (0.76) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL4920242 | 0.82 | RAB9A (0.79) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL16562091 | 0.81 | RAB9A (0.78) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL12199352 | 0.81 | NPC1 (0.71) | RAB9ANPC1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |