Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KLK7 | P49862 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.45 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3064874 | 0.95 | CASR (0.48) | CASREPHX2KLK7ATMEPHX1 | |
| SCHEMBL3072576 | 0.94 | KLK7 (0.47) | CASREPHX2KLK7ATMEPHX1 | |
| SCHEMBL13091919 | 0.83 | CASR (0.48) | CASREPHX2KLK7ATMEPHX1 | |
| SCHEMBL3052535 | 0.82 | EPHX1 (0.52) | CASREPHX1PPARAPPARGMEN1 | |
| SCHEMBL4017006 | 0.81 | HDAC6 (0.52) | CASREPHX2KLK7ATMEPHX1 | |
| SCHEMBL3051984 | 0.77 | HDAC1 (0.55) | EPHX1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL3062487 | 0.76 | NPC1 (0.51) | EPHX2PPARAPPARGALDH1A1MEN1 | |
| SCHEMBL3069314 | 0.76 | ALDH1A1 (0.54) | EPHX1ALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL3067422 | 0.76 | ALDH1A1 (0.54) | EPHX1ALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL3069989 | 0.76 | ALDH1A1 (0.69) | CASRALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261796-A1 | Use of Novel Compounds for IBD Treatment | FERRING B.V. (NL) | 2010-10-14 | — | — | US | claimed |
| US-20100105777-A1 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC. (US) | 2010-04-29 | — | — | US | claimed |
| US-7504538-B2 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2009-03-17 | — | — | US | claimed |
| EP-1874283-A2 | USE OF NOVEL COMPOUNDS FOR IBD TREATMENT | Ferring BV (NL) | 2008-01-09 | — | — | EP | claimed |
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2007-08-23 | — | — | US | claimed |
| WO-2006116399-A2 | USE OF NOVEL COMPOUNDS FOR IBD TREATMENT | FERRING B.V. (NL) | 2006-11-02 | — | — | WO | claimed |
| EP-1675822-A2 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | Cara Therapeutics, Inc. (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005037798-A2 | AMIDE OR THIOMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC (US) | 2005-04-28 | — | — | WO | claimed |
| US-20100261796-A1 | Use of Novel Compounds for IBD Treatment | FERRING B.V. (NL) | 2010-10-14 | — | — | US | disclosed |
| US-20100105777-A1 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-7504538-B2 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | CARA THERAPEUTICS, INC. (US) | 2007-08-23 | — | — | US | disclosed |
| EP-1675822-A2 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | Cara Therapeutics, Inc. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037798-A2 | AMIDE OR THIOMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | CARA THERAPEUTICS, INC (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261796-A1 | Use of Novel Compounds for IBD Treatment | TPMT, FABP2, SLC10A2 | CASR 4403/4885EPHX2 1218/4885KLK7 4260/4885 |
| US-20070197653-A1 | Amide or thioamide derivatives and their use in the treatment of pain | TRPA1, TRPV1, TST | CASR 3991/4885EPHX2 1131/4885KLK7 4092/4885 |
| US-20100105777-A1 | AMIDE OR THIOAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PAIN | TRPA1, TRPV1, TST | CASR 3991/4885EPHX2 1131/4885KLK7 4092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.