Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25351564 | 1.00 | MEN1 (0.50) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL30535367 | 0.89 | MEN1 (0.45) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL25351103 | 0.89 | MEN1 (0.45) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL30543946 | 0.89 | DHX9 (0.53) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL25368280 | 0.89 | DHX9 (0.53) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL25368447 | 0.87 | HPGD (0.51) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31560992 | 0.87 | ADORA3 (0.51) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL25351576 | 0.85 | MEN1 (0.51) | MEN1KMT2AHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL25368915 | 0.85 | RAB9A (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL30543940 | 0.85 | RAB9A (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119923385-A | Inhibitors of RNA helicase DHX9 and uses thereof | 埃克森特治疗公司 | 2025-05-02 | — | — | CN | disclosed |
| WO-2025080900-A1 | INHIBITORS OF THE RNA HELICASE DHX9 FOR USE IN THE TREATMENT OF DNA DAMAGE REPAIR DEFICIENT, HOMOLOGOUS RECOMBINATION DEFICIENT, AND CANCERS HAVING A BRCA LOSS OF FUNCTION MUTATION | ACCENT THERAPEUTICS, INC. (US) | 2025-04-17 | — | — | WO | disclosed |
| EP-4479138-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | Accent Therapeutics, Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023154519-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |