Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25401274 | 0.87 | TDP1 (0.53) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL25401270 | 0.87 | TDP1 (0.53) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL5360860 | 0.85 | ADRA2B (0.56) | ALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL17271883 | 0.80 | HTT (0.47) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL20226707 | 0.78 | PYCR1 (0.47) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL30537552 | 0.78 | ALDH1A1 (0.50) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL30832274 | 0.77 | ALDH1A1 (0.45) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL17271536 | 0.76 | HTT (0.51) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL28595152 | 0.76 | HTT (0.50) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL14438327 | 0.76 | APLNR (0.55) | TDP1ALDH1A1HTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12209102-B2 | Heterocyclic compounds and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2025-01-28 | — | — | US | disclosed |
| EP-4489738-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Kumquat Biosciences Inc. (US) | 2025-01-15 | — | — | EP | disclosed |
| US-20240425522-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2024-12-26 | — | — | US | disclosed |
| WO-2023172737-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | KUMQUAT BIOSCIENCES INC. (US) | 2023-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240425522-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | TP53, HRAS, KRAS | TDP1 757/4885ALDH1A1 3175/4885HTT 430/4885 |
| US-12209102-B2 | Heterocyclic compounds and uses thereof | TP53, HRAS, KRAS | TDP1 757/4885ALDH1A1 3175/4885HTT 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.