Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | LTK | P29376 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.61 |
| ▸ | PRKX | P51817 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.61 |
| ▸ | MST1R | Q04912 | 1/20 | 0.61 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5054128 | 0.85 | PLK4 (0.54) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL27784126 | 0.83 | PLK4 (0.53) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL29696521 | 0.76 | PLK4 (1.00) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL2264295 | 0.76 | PLK4 (1.00) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL29521081 | 0.74 | PLK4 (0.50) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL29728560 | 0.74 | KMT2A (0.50) | L3MBTL1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL5483794 | 0.73 | HPGD (0.62) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL30788421 | 0.72 | NOS1 (0.50) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL20184106 | 0.72 | NOS1 (0.55) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Oxalic Acid SCHEMBL28217953 | 0.72 | PLK4 (0.90) | PLK4CHEK1AURKADAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116490201-A | Inhibitors of YAP/TAZ-TEAD tumor proteins, their synthesis and use | 布里奇恩生物科学公司 | 2023-07-25 | — | — | CN | disclosed |