Sugi Predict

Sugi Predict / Compounds / SCHEMBL5483794

SCHEMBL5483794

SCHEMBL5483794

COc1cccc2cn[nH]c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 4/20 0.62
▸ KDM4E B2RXH2 3/20 0.62
▸ ALDH1A1 P00352 3/20 0.62
▸ NOS1 P29475 3/20 0.55
▸ RET P07949 2/20 0.49
▸ HSD17B10 Q99714 3/20 0.47
▸ MAPT P10636 3/20 0.47
▸ PLK4 O00444 1/20 0.47
▸ CHEK1 O14757 1/20 0.47
▸ AURKA O14965 1/20 0.47
▸ DAPK3 O43293 1/20 0.47
▸ MAP4K4 O95819 1/20 0.47
▸ CSF1R P07333 1/20 0.47
▸ FGFR1 P11362 1/20 0.47
▸ PDGFRA P16234 1/20 0.47
▸ LTK P29376 1/20 0.47
▸ KDR P35968 1/20 0.47
▸ MAP2K2 P36507 1/20 0.47
▸ FLT3 P36888 1/20 0.47
▸ CSNK1A1 P48729 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10595701 0.83 ALDH1A1 (0.56) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL5583144 0.82 KDM4E (0.56) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL15505902 0.79 NOS1 (0.50) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL19920463 0.79 RPS6KA2 (0.47) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL27236463 0.78 NOS1 (0.45) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL1552041 0.77 ALDH1A1 (1.00) HPGDKDM4EALDH1A1HSD17B10MAPT
SCHEMBL3533761 0.77 NOS1 (0.47) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL27784126 0.77 PLK4 (0.53) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL29317050 0.77 NOS1 (0.51) HPGDKDM4EALDH1A1NOS1RET
SCHEMBL30345130 0.77 ALDH1A1 (0.54) HPGDKDM4EALDH1A1RETHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3706743-A1 MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE Howard Hughes Medical Institute (US) 2020-09-16 — — EP claimed
CN-111556751-A Modified ligand-gated ion channels and methods of use 霍华休斯医学研究院 2020-08-18 — — CN claimed
US-20260098076-A1 MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE HUGHES HOWARD MED INST (US) 2026-04-09 — — US disclosed
US-12570705-B2 Modified ligand-gated ion channels and methods of use HOWARD HUGHES MEDICAL INSTITUTE (US) 2026-03-10 — — US disclosed
US-12247064-B2 Modified ligand-gated ion channels and methods of use HOWARD HUGHES MEDICAL INSTITUTE (US) 2025-03-11 — — US disclosed
CN-119120484-A Modified ligand-gated ion channels and methods of use 霍华休斯医学研究院 2024-12-13 — — CN disclosed
CN-118903472-A Modified ligand-gated ion channels and methods of use 霍华休斯医学研究院 2024-11-08 — — CN disclosed
US-20230391774-A1 Novel Compounds AC IMMUNE SA (CH) 2023-12-07 — — US disclosed
EP-4229052-A1 NOVEL COMPOUNDS AC Immune SA (CH) 2023-08-23 — — EP disclosed
CN-116568684-A Novel compounds AC免疫有限公司 2023-08-08 — — CN disclosed
EP-3325486-B1 POLYNITROGEN COMPOUNDS AND USES THEREOF AS FLUORESCENT CHROMOPHORES UNIV ORLEANS (FR) 2023-05-24 — — EP disclosed
WO-2017013135-A1 POLYNITROGEN COMPOUNDS AND USES THEREOF AS FLUORESCENT CHROMOPHORES UNIVERSITE D'ORLEANS (FR) 2017-01-26 — — WO disclosed
WO-2017013135-A1 POLYNITROGEN COMPOUNDS AND USES THEREOF AS FLUORESCENT CHROMOPHORES UNIVERSITE D'ORLEANS (FR) 2017-01-26 — — WO disclosed
WO-2015134366-A1 HIV PROTEASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2015-09-11 — — WO disclosed
US-20130253185-A1 NOVEL CATALYSTS DALHOUSIE UNIVERSITY (CA) 2013-09-26 — — US disclosed
WO-2012068335-A2 NOVEL CATALYSTS DALHOUSIE UNIVERSITY (CA) 2012-05-24 — — WO disclosed
US-7217724-B2 Indole, indazole, and benzazole derivative DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2007-05-15 — — US disclosed
US-20060063762-A1 Indole indazole and benzazole derivative DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2006-03-23 — — US disclosed
EP-1514869-A1 INDOLE, INDAZOLE, AND BENZAZOLE DERIVATIVE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2005-03-16 — — EP disclosed
WO-1991001316-A1 NEW 9-AZABICYCLO[3.3.1]NONANE-DERIVATE BEECHAM GROUP PLC (GB) 1991-02-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247064-B2 Modified ligand-gated ion channels and methods of use GRIK4, GRIK2, GRIK5 HPGD 3928/4885KDM4E 4061/4885ALDH1A1 3969/4885
US-20060063762-A1 Indole indazole and benzazole derivative ADRB3, ADRA2C, ADRB2 HPGD 3173/4885KDM4E 1432/4885ALDH1A1 847/4885
US-20260098076-A1 MODIFIED LIGAND-GATED ION CHANNELS AND METHODS OF USE CHRNG, CHRNA7, CHRNA6 HPGD 4707/4885KDM4E 2819/4885ALDH1A1 4503/4885
US-12570705-B2 Modified ligand-gated ion channels and methods of use CHRNA7, CHRNG, CHRNA6 HPGD 3181/4885KDM4E 2418/4885ALDH1A1 4471/4885
US-20230391774-A1 Novel Compounds MAPT, PSEN2, PSEN1 HPGD 3020/4885KDM4E 4326/4885ALDH1A1 3560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.