Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | PRKX | P51817 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | MST1R | Q04912 | 1/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27784126 | 0.85 | PLK4 (0.53) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL30539134 | 0.85 | PLK4 (0.61) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL259689 | 0.75 | PLK4 (0.72) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL29520722 | 0.75 | PLK4 (0.72) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL2315260 | 0.75 | METAP2 (0.47) | NOS1HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5483794 | 0.74 | HPGD (0.62) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL30788421 | 0.74 | NOS1 (0.50) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL20184106 | 0.74 | NOS1 (0.55) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL4730864 | 0.74 | BCHE (0.67) | HPGDHSD17B10MEN1MAPTKMT2A | |
| SCHEMBL11578958 | 0.73 | PLK4 (0.59) | PLK4CHEK1AURKADAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888593-A2 | THIENOPYRIDINES | Merck Patent GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006125531-A2 | THIENOPYRIDINES | MERCK PATENT GMBH (DE) | 2006-11-30 | — | — | WO | disclosed |