SCHEMBL3054256

SCHEMBL3054256

COc1c(Cl)ccc(-c2cc(N)c(Cl)c(C(=O)NOCC=CCl)n2)c1F

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEP1B Q16820 1/20 0.35
SCN10A Q9Y5Y9 3/20 0.32
KLKB1 P03952 1/20 0.32
ROCK2 O75116 1/20 0.31
ROCK1 Q13464 1/20 0.31
VEGFA P15692 1/20 0.31
FLT1 P17948 1/20 0.31
EGLN1 Q9GZT9 1/20 0.31
EGLN3 Q9H6Z9 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
GRM4 Q14833 1/20 0.31
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
TAS1R3 Q7RTX0 1/20 0.30
TAS1R1 Q7RTX1 1/20 0.30
TAS1R2 Q8TE23 1/20 0.30
PTGES O14684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3054246 1.00 MEP1B (0.35) MEP1BSCN10AKLKB1ROCK2ROCK1
SCHEMBL3059964 0.93 MEP1B (0.35) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL3059971 0.93 MEP1B (0.35) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL3052752 0.92 MEP1B (0.34) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL3052748 0.92 MEP1B (0.34) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL694400 0.90 MEP1B (0.35) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL694248 0.88 MEP1B (0.35) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL694666 0.88 MEP1B (0.35) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL693815 0.87 ALDH1A1 (0.35) MEP1BSCN10AKLKB1KDM4EALDH1A1
SCHEMBL693573 0.86 ALDH1A1 (0.37) MEP1BKLKB1KDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS HASPIN, NOTUM, CANX MEP1B 3838/4885SCN10A 1792/4885KLKB1 4853/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.