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Sugi Predict / Compounds / SCHEMBL694248

SCHEMBL694248

SCHEMBL694248

CCONC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)cc(N)c1Cl

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEP1B Q16820 1/20 0.35
▸ MAPK1 P28482 2/20 0.34
▸ MAPK9 P45984 2/20 0.34
▸ PRKD2 Q9BZL6 2/20 0.34
▸ PRKD3 O94806 1/20 0.34
▸ MAPK8 P45983 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ TAS1R3 Q7RTX0 2/20 0.34
▸ TAS1R1 Q7RTX1 2/20 0.34
▸ KLKB1 P03952 1/20 0.34
▸ ALDH1A1 P00352 3/20 0.33
▸ KDM4E B2RXH2 2/20 0.33
▸ GAA P10253 1/20 0.33
▸ CSF1R P07333 1/20 0.33
▸ CSNK1D P48730 1/20 0.33
▸ GRM4 Q14833 1/20 0.33
▸ TAS1R2 Q8TE23 1/20 0.33
▸ KCNH2 Q12809 2/20 0.32
▸ HTR3E A5X5Y0 1/20 0.32
▸ SLC22A1 O15245 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL693815 0.93 ALDH1A1 (0.35) MEP1BMAPK1MAPK9PRKD2PRKD3
SCHEMBL694666 0.92 MEP1B (0.35) MEP1BTAS1R3TAS1R1KLKB1ALDH1A1
SCHEMBL693654 0.91 SMN1; SMN2 (0.37) MEP1BTAS1R3TAS1R1KLKB1ALDH1A1
SCHEMBL693573 0.90 ALDH1A1 (0.37) MEP1BMAPK1MAPK9PRKD2PRKD3
SCHEMBL28733112 0.89 ALDH1A1 (0.41) MEP1BTAS1R3TAS1R1KLKB1ALDH1A1
SCHEMBL693348 0.89 MEP1B (0.38) MEP1BTAS1R3TAS1R1KLKB1ALDH1A1
SCHEMBL695140 0.89 KDM4E (0.37) MEP1BMAPK9MAPK8MAPK10KLKB1
SCHEMBL693569 0.89 ALPL (0.34) MEP1BTAS1R3TAS1R1KLKB1ALDH1A1
SCHEMBL693799 0.89 MEP1B (0.34) MEP1BTAS1R3TAS1R1KLKB1ALDH1A1
SCHEMBL3052752 0.89 MEP1B (0.34) MEP1BMAPK1MAPK9PRKD2PRKD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 — — US claimed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 — — US disclosed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 — — US disclosed
EP-2421832-B1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2013-12-18 — — EP disclosed
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2013-12-05 — — US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 — — US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 — — US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 — — US disclosed
EP-2421832-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS Dow AgroSciences LLC (US) 2012-02-29 — — EP disclosed
WO-2010099279-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — WO disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS HASPIN, NOTUM, CANX MEP1B 3838/4885MAPK1 3664/4885MAPK9 3009/4885
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS NPEPPS, DNPEP, HASPIN MEP1B 3773/4885MAPK1 3279/4885MAPK9 2892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.