SCHEMBL693573

SCHEMBL693573

COc1c(Cl)ccc(-c2cc(N)c(Cl)c(C(=O)NOCC(=O)O)n2)c1F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
TSHR P16473 1/20 0.37
MEP1B Q16820 1/20 0.34
KLKB1 P03952 1/20 0.33
ALPL P05186 4/20 0.33
CTSA P10619 5/20 0.33
KDM4E B2RXH2 2/20 0.32
GAA P10253 1/20 0.32
PDCD1LG2 Q9BQ51 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
GRM4 Q14833 1/20 0.32
ALOX5AP P20292 1/20 0.32
FEN1 P39748 1/20 0.32
TAS1R3 Q7RTX0 1/20 0.32
TAS1R1 Q7RTX1 1/20 0.32
TAS1R2 Q8TE23 1/20 0.32
HSD17B10 Q99714 1/20 0.32
PRKD3 O94806 1/20 0.32
MAPK1 P28482 1/20 0.32
MAPK8 P45983 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL693799 0.91 MEP1B (0.34) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL693563 0.90 MEP1B (0.33) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL693947 0.90 KLKB1 (0.34) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL694248 0.90 MEP1B (0.35) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL694666 0.90 MEP1B (0.35) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL693815 0.89 ALDH1A1 (0.35) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL28939828 0.88 EGLN1 (0.39) MEP1BKDM4E
SCHEMBL693348 0.88 MEP1B (0.38) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL28733112 0.88 ALDH1A1 (0.41) ALDH1A1MEP1BKLKB1ALPLKDM4E
SCHEMBL694228 0.88 ALOX5AP (0.42) ALDH1A1ALOX5APFEN1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 US claimed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 US disclosed
US-8889694-B2 N-alkoxyamides of 6-(substituted phenyl)-4-aminopicolinates and 2-(substituted phenyl)-6-amino-4-pyrimidinecarboxylates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2014-11-18 US disclosed
EP-2421832-B1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2013-12-18 EP disclosed
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2013-12-05 US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 US disclosed
US-8536331-B2 N-alkoxyamides of 6-(trisubstituted phenyl)-4-aminopicolinates and their use as selective herbicides for crops DOW AGROSCIENCES, LLC. (US) 2013-09-17 US disclosed
EP-2421832-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS Dow AgroSciences LLC (US) 2012-02-29 EP disclosed
WO-2010099279-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 WO disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 US disclosed
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS DOW AGROSCIENCES LLC (US) 2010-09-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222221-A1 N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS HASPIN, NOTUM, CANX ALDH1A1 1549/4885TSHR 4112/4885MEP1B 3838/4885
US-20130324412-A1 N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS NPEPPS, DNPEP, HASPIN ALDH1A1 1527/4885TSHR 4157/4885MEP1B 3773/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.