Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20195653 | 0.84 | LMNA (0.39) | LMNACYP3A4TRPM8TSHRSIGMAR1 | |
| SCHEMBL30545003 | 0.79 | POLB (0.35) | TSHRALDH1A1TP53KDM4EMEN1 | |
| SCHEMBL30545019 | 0.79 | ESR1 (0.32) | — | |
| SCHEMBL29624292 | 0.77 | SIGMAR1 (0.43) | LMNACYP3A4TRPM8TSHRSIGMAR1 | |
| SCHEMBL28501086 | 0.77 | LMNA (0.50) | LMNACYP3A4TRPM8SIGMAR1ALDH1A1 | |
| SCHEMBL11592385 | 0.77 | TRPM8 (0.49) | LMNACYP3A4TRPM8TSHRSIGMAR1 | |
| SCHEMBL10783489 | 0.74 | SIGMAR1 (0.41) | LMNACYP3A4TRPM8TSHRSIGMAR1 | |
| SCHEMBL19909912 | 0.74 | SIGMAR1 (0.41) | LMNACYP3A4TRPM8TSHRSIGMAR1 | |
| SCHEMBL9298349 | 0.73 | NPSR1 (0.46) | LMNACYP3A4TRPM8TSHRALDH1A1 | |
| SCHEMBL19527508 | 0.73 | TP53 (0.39) | LMNACYP3A4TRPM8SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655536-A | Class N 1 -aryl-3-fluoroalkyl-5-fluoropyrazole compound, and preparation method and application thereof | 天津大学 | 2023-08-29 | — | — | CN | disclosed |