Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL67549 | 0.91 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL231340 | 0.91 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL67551 | 0.91 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27537584 | 0.91 | TSHR (0.45) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Methacrylic Acid SCHEMBL307309 | 0.91 | TDP1 (0.36) | TSHRTP53ALDH1A1HSD17B10TDP1 | |
| Crotonic Acid SCHEMBL11062320 | 0.90 | — | — | |
| Methacrylic Acid SCHEMBL10777668 | 0.89 | LMNA (0.43) | TSHRTP53ALDH1A1HSD17B10TDP1 | |
| Methacrylic Acid SCHEMBL3643411 | 0.89 | TDP1 (0.35) | ALDH1A1HSD17B10TDP1 | |
| Fumaric Acid SCHEMBL7949814 | 0.89 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL28185469 | 0.89 | TSHR (0.43) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497315-B2 | Method for producing dispersions and use thereof | AKZO NOBEL N.V. (NL) | 2013-07-30 | — | — | US | disclosed |
| US-8393391-B2 | Dry cement formulation for cementing holes in the earth | AKZO NOBEL N.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| US-20100221418-A1 | PAVING JOINT MORTARS | STADTBAEUMER SIEGMUND KSIAZEK | 2010-09-02 | — | — | US | disclosed |
| US-20100139920-A1 | DRY CEMENT FORMULATION FOR CEMENTING HOLES IN THE EARTH | AKZO NOBEL COATINGS INTERNATIONAL B.V. (NL) | 2010-06-10 | — | — | US | disclosed |
| US-20100081736-A1 | METHOD FOR PRODUCING DISPERSIONS AND USE THEREOF | CELANESE SWITZERLAND AG (CH) | 2010-04-01 | — | — | US | disclosed |