SCHEMBL3054907

SCHEMBL3054907

C=C(C)Cn1c(C(F)(F)F)ccc(C(=O)OC)c1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.41
XBP1 P17861 2/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
CFTR P13569 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
PLA2G1B P04054 1/20 0.38
ATG4B Q9Y4P1 1/20 0.38
BRD4 O60885 2/20 0.36
KDM4E B2RXH2 5/20 0.36
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
HPGD P15428 2/20 0.34
TSHR P16473 1/20 0.34
CASP1 P29466 1/20 0.34
HSD17B10 Q99714 1/20 0.34
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3051487 0.85 LMNA (0.44) LMNAXBP1MEN1KMT2ANPC1
SCHEMBL3051490 0.82 LMNA (0.44) LMNAXBP1MEN1KMT2ANPC1
SCHEMBL3052226 0.79 LMNA (0.41) LMNAXBP1MEN1KMT2ANPC1
SCHEMBL3049665 0.78 LMNA (0.41) LMNAXBP1MEN1KMT2ANPC1
SCHEMBL3045673 0.76 RAB9A (0.51) LMNAMEN1KMT2ANPC1RAB9A
SCHEMBL31186107 0.68 LMNA (0.39) LMNAXBP1MEN1KMT2AL3MBTL1
SCHEMBL31186143 0.68 LMNA (0.41) LMNAXBP1MEN1KMT2ANPC1
SCHEMBL31185963 0.67 KDM4E (0.40) LMNAXBP1MEN1KMT2ANPC1
SCHEMBL31186030 0.66 KDM4E (0.40) LMNAXBP1MEN1KMT2ANPC1
SCHEMBL17686784 0.65 ALDH1A1 (0.40) LMNAMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1982978-B1 PYRIDONE DERIVATIVE AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO (JP) 2014-08-27 EP disclosed
US-8076487-B2 Pyridone derivative and herbicide KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2011-12-13 US disclosed
US-20100222592-A1 Pyridone Derivative and Herbicide KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2010-09-02 US disclosed
EP-1982978-A1 PYRIDONE DERIVATIVE AND HERBICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2008-10-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100222592-A1 Pyridone Derivative and Herbicide PDXK, PNPO, CBR3 LMNA 3316/4885XBP1 3967/4885MEN1 3213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.