Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.35 |
| ▸ | ATXN2 | Q99700 | 4/20 | 0.35 |
| ▸ | CCR2 | P41597 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25324202 | 1.00 | FAAH (0.38) | FAAHTEAD1ENPP2ATXN2CCR2 | |
| SCHEMBL25325112 | 0.87 | TEAD1 (0.44) | TEAD1CCR2HDAC3HDAC4HDAC1 | |
| SCHEMBL25324075 | 0.84 | P2RX7 (0.37) | TEAD1MGLL | |
| SCHEMBL25325226 | 0.84 | FAAH (0.38) | FAAHTEAD1CCR2FFAR4MGLL | |
| SCHEMBL25322265 | 0.83 | POLB (0.39) | TEAD1ENPP2ATXN2POLBMGLL | |
| SCHEMBL30553285 | 0.82 | FAAH (0.36) | FAAHMGLL | |
| SCHEMBL25325576 | 0.82 | FAAH (0.36) | FAAHMGLL | |
| SCHEMBL25325835 | 0.81 | MGLL (0.37) | TEAD1ENPP2ATXN2MGLL | |
| SCHEMBL25323130 | 0.81 | PDE2A (0.37) | TEAD1BTKMGLLKCNH2 | |
| SCHEMBL25322558 | 0.79 | BCHE (0.41) | ENPP2ATXN2HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469446-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | claimed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | claimed |
| EP-4469446-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | disclosed |