Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.34 |
| ▸ | MGLL | Q99685 | 4/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.33 |
| ▸ | IL1B | P01584 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | MAT2A | P31153 | 2/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CCR6 | P51684 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25326138 | 1.00 | DRD2 (0.37) | DRD2DRD3HCRTR2MGLLHCRTR1 | |
| SCHEMBL25325915 | 0.81 | MGLL (0.43) | MGLL | |
| SCHEMBL30553315 | 0.81 | MGLL (0.43) | MGLL | |
| SCHEMBL25297019 | 0.81 | DRD2 (0.41) | DRD2DRD3HCRTR2HCRTR1IL1B | |
| SCHEMBL30553206 | 0.80 | LOXL2 (0.37) | HCRTR2MGLLHCRTR1 | |
| SCHEMBL25324006 | 0.80 | LOXL2 (0.37) | HCRTR2MGLLHCRTR1 | |
| SCHEMBL30553201 | 0.80 | CCNK (0.38) | MGLLHCRTR1CCNKCDK12 | |
| SCHEMBL25324903 | 0.80 | CCNK (0.38) | MGLLHCRTR1CCNKCDK12 | |
| SCHEMBL30720318 | 0.80 | MGLL (0.56) | DRD2DRD3HCRTR2MGLLHCRTR1 | |
| SCHEMBL25325093 | 0.80 | MGLL (0.35) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469446-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | claimed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | claimed |
| EP-4469446-A1 | NEW HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2024-12-04 | — | — | EP | disclosed |
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | disclosed |