Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 11/20 | 0.40 |
| ▸ | THRA | P10827 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527186 | 0.87 | RORC (0.39) | RORCGAATHRBTHRA | |
| SCHEMBL29066177 | 0.87 | RORC (0.39) | RORCGAATHRBTHRA | |
| SCHEMBL29527194 | 0.81 | THRB (0.44) | RORCTHRBTHRA | |
| SCHEMBL29066191 | 0.79 | THRB (0.41) | GAATHRBTHRA | |
| SCHEMBL29527123 | 0.79 | THRB (0.41) | GAATHRBTHRA | |
| SCHEMBL29066250 | 0.75 | MAPT (0.35) | RORCGAATHRBTHRAALDH1A1 | |
| SCHEMBL30083001 | 0.71 | THRB (0.43) | RORCTHRBTHRAALDH1A1 | |
| SCHEMBL28650685 | 0.71 | THRB (0.43) | RORCTHRBTHRAALDH1A1 | |
| SCHEMBL6864242 | 0.71 | THRB (0.49) | RORCTHRBTHRA | |
| SCHEMBL28650050 | 0.70 | RORC (0.37) | RORCTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |