Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.41 |
| ▸ | THRA | P10827 | 8/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527123 | 1.00 | THRB (0.41) | THRBTHRAPIK3R1PIK3CAP2RX3 | |
| SCHEMBL24449953 | 0.85 | THRB (0.38) | THRBTHRAPIK3R1PIK3CAP2RX3 | |
| SCHEMBL29527194 | 0.83 | THRB (0.44) | THRBTHRA | |
| SCHEMBL30558161 | 0.79 | RORC (0.41) | THRBTHRAGAA | |
| SCHEMBL29527186 | 0.76 | RORC (0.39) | THRBTHRAPIK3R1PIK3CAGAA | |
| SCHEMBL29066177 | 0.76 | RORC (0.39) | THRBTHRAPIK3R1PIK3CAGAA | |
| SCHEMBL6864460 | 0.75 | THRB (0.48) | THRBTHRAPOLBGAAGFER | |
| SCHEMBL30083001 | 0.75 | THRB (0.43) | THRBTHRAP2RX3P2RX2DHFR | |
| SCHEMBL28650685 | 0.75 | THRB (0.43) | THRBTHRAP2RX3P2RX2DHFR | |
| SCHEMBL115578 | 0.74 | PIK3R1 (0.40) | PIK3R1PIK3CAP2RX3P2RX2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |