Guanosine

Guanosine

SCHEMBL3055871

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=c1[nH]cnc2nc[nH]c12

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.63
HINT1 P49773 5/20 0.58
NT5E P21589 2/20 0.58
PAX8 Q06710 1/20 0.57
GSK3A P49840 2/20 0.57
RPS6KA3 P51812 2/20 0.57
MAPK14 Q16539 2/20 0.57
PNP P00491 2/20 0.55
TGM2 P21980 1/20 0.54
LMNA P02545 1/20 0.52
HIF1A Q16665 1/20 0.52
ADORA2A P29274 2/20 0.52
ADORA3 P0DMS8 1/20 0.52
ADORA2B P29275 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL29045171 0.97 HPGD (0.60) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL8995759 0.95 HPGD (0.62) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL936682 0.93 HPGD (0.55) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL9138605 0.92 HPGD (0.58) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL24049416 0.90 HPGD (0.76) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL24049417 0.90 HPGD (0.76) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL11986902 0.90 HPGD (0.76) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL24049467 0.90 HPGD (0.76) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL20750695 0.90 HPGD (0.76) HPGDHINT1NT5EPAX8GSK3A
Guanosine SCHEMBL413586 0.90 HPGD (0.76) HPGDHINT1NT5EPAX8GSK3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116194780-A Method for detecting beta-sheet aggregate form of protein forming beta-sheet aggregate CISBIO生物试验公司 2023-05-30 CN disclosed
US-20230091315-A1 ANTI-G-PROTEIN ALPHA ANTIBODY CISBIO BIOASSAYS (FR) 2023-03-23 US disclosed
CN-115397858-A anti-G protein alpha antibody CISBIO生物试验公司 2022-11-25 CN disclosed
EP-3658913-A1 METHOD FOR MEASURING MODULATION IN THE ACTIVITY OF A G PROTEIN-COUPLED RECEPTOR CISBIO BIOASSAYS (FR) 2020-06-03 EP disclosed
CN-105497701-A Natural medicine for treating gout diseases and preparation method thereof DU ZHIZHENG 2016-04-20 CN disclosed
CN-104940449-A Medicine for treating gout LUO CAILIAN 2015-09-30 CN disclosed
CN-103142655-B Composite probiotics for treating podagra and preparation method thereof XUE SONGXIAO (CN) 2014-10-29 CN disclosed
EP-2087355-B1 METHOD FOR THE DETECTION OF POST-TRANSLATIONAL MODIFICATIONS CISBIO BIOASSAYS (FR) 2014-09-24 EP disclosed
WO-2014063703-A1 MONOCLONAL ANTIBODIES STATENS SERUM INSTITUT (DK) 2014-05-01 WO disclosed
US-8663928-B2 Method for the detection of post-translational modifications CIS BIO INTERNATIONAL (FR) 2014-03-04 US disclosed
US-5675063-A EXPRESSES TWO ONCOGENES AND IS CAPABLE OF FUSING WITH ACTIVATED B-LYMPHOCYTE RESULTING IN HYBRIDOMA THAT PRODUCES IMMUNOGLOBULINS LOYOLA UNIVERSITY OF CHICAGO (US) 1997-10-07 US disclosed
US-5573920-A Antibodies, and methods for their use SURFACE ACTIVE LIMITED (GB) 1996-11-12 US disclosed
EP-0511011-B1 Novel antibodies and methods for their use SURFACE ACTIVE LTD (GB) 1996-10-23 EP disclosed
WO-1996027004-A1 AN IMMORTALIZED MAMMAL HYBRIDOMA FUSION PARTNER LOYOLA UNIVERSITY OF CHICAGO (US) 1996-09-06 WO disclosed
US-5527895-A CLEAVE SPECIFIC RNA SEQUENCES INTO A FRAGMENT HAVING A 5'HYDROXYL AND A FRAGMENT HAVING A 2',3'CYCLIC PHOSPHATE; PRODUCTS RESEMBLE THOSE RESULTING FROM THE NATURAL HYDROLYSIS OF RNA THE BOARD OF REGENTS FOR NORTHERN ILLINOIS UNIVERSITY OF DEKALB (US) 1996-06-18 US disclosed
EP-0666749-A1 ENANTIOMERICALLY PURE beta-D-DIOXOLANE NUCLEOSIDES WITH SELECTIVE ANTI-HEPATITIS B VIRUS ACTIVITY EMORY UNIVERSITY (US) 1995-08-16 EP disclosed
WO-1994009793-A1 ENANTIOMERICALLY PURE β-D-DIOXOLANE NUCLEOSIDES WITH SELECTIVE ANTI-HEPATITIS B VIRUS ACTIVITY EMORY UNIVERSITY (US) 1994-05-11 WO disclosed
EP-0582595-A1 NOVEL ANTIBODIES, AND METHODS FOR THEIR USE SURFACE ACTIVE LIMITED (GB) 1994-02-16 EP disclosed
WO-1992019973-A1 NOVEL ANTIBODIES, AND METHODS FOR THEIR USE SURFACE ACTIVE LIMITED (GB) 1992-11-12 WO disclosed
EP-0511011-A1 Novel antibodies and methods for their use SURFACE ACTIVE LIMITED (GB) 1992-10-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230091315-A1 ANTI-G-PROTEIN ALPHA ANTIBODY GNG2, GNAI3, GNAI2 HPGD 4428/4885HINT1 683/4885NT5E 257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.