Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 4/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30560068 | 0.87 | PTK2 (0.52) | ALKLCKEGFRCCNKCCNA2 | |
| SCHEMBL30560065 | 0.87 | SYK (0.55) | SYKCCNKCCNA2CDK2CCND3 | |
| SCHEMBL30560072 | 0.86 | CCND3 (0.53) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL30560067 | 0.81 | MAP4K1 (0.50) | BRD4JAK3 | |
| SCHEMBL28228697 | 0.80 | LCK (0.60) | ALKLCKMAPK14EGFRBRD4 | |
| SCHEMBL4492001 | 0.79 | SYK (0.62) | ALKLCKMAPK14SLC2A1BRD4 | |
| SCHEMBL30463630 | 0.77 | ALK (0.65) | ALKLCKMAPK14EGFRBRD4 | |
| SCHEMBL2951233 | 0.77 | ALK (0.62) | ALKLCKMAPK14EGFRBRD4 | |
| SCHEMBL2961783 | 0.77 | EGFR (0.60) | ALKLCKMAPK14EGFRCCNK | |
| SCHEMBL29310350 | 0.75 | SLC2A1 (0.60) | ALKLCKSLC2A1EGFRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3733184-B1 | PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2023-08-30 | — | — | EP | claimed |