Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 7/20 | 0.52 |
| ▸ | WEE1 | P30291 | 6/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | BTK | Q06187 | 3/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | PAK4 | O96013 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30560062 | 0.87 | ALK (0.53) | ALKJAK3JAK2LCKKDR | |
| SCHEMBL30560065 | 0.84 | SYK (0.55) | JAK3AURKAJAK2PRKD3IGF1R | |
| SCHEMBL17466591 | 0.80 | CDK9 (0.59) | PTK2WEE1ALKPDGFRAJAK3 | |
| SCHEMBL16069915 | 0.78 | CDK9 (0.55) | PTK2WEE1ALKPDGFRAJAK3 | |
| SCHEMBL19409829 | 0.77 | RAD52 (0.62) | PTK2WEE1ALKPDGFRAJAK3 | |
| SCHEMBL21596401 | 0.74 | WEE1 (0.65) | PTK2WEE1ALKPDGFRAJAK3 | |
| SCHEMBL30560072 | 0.74 | CCND3 (0.53) | CDK7CDK5CDK9CDK2CDK6 | |
| SCHEMBL30560066 | 0.72 | HDAC3 (0.59) | PTK2AURKAKDRCDK5NTRK2 | |
| SCHEMBL30560067 | 0.72 | MAP4K1 (0.50) | JAK3FLT3TBK1 | |
| SCHEMBL29371810 | 0.71 | KDM1A (0.62) | PTK2WEE1ALKPDGFRAJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3733184-B1 | PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2023-08-30 | — | — | EP | claimed |