Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.48 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30560062 | 0.87 | ALK (0.53) | SYKJAK2JAK3CCND3CDK2 | |
| SCHEMBL30560068 | 0.84 | PTK2 (0.52) | IGF1RJAK2JAK3MAPTCCND3 | |
| SCHEMBL29972048 | 0.74 | PLK4 (0.68) | SYKIGF1RJAK2TP53MAPT | |
| SCHEMBL23704673 | 0.73 | PKMYT1 (0.69) | SYKIGF1RJAK3PKMYT1CCND3 | |
| SCHEMBL30560072 | 0.73 | CCND3 (0.53) | CCND3CDK4CDK2CDK9CDK6 | |
| SCHEMBL30560067 | 0.73 | MAP4K1 (0.50) | JAK3TBK1 | |
| SCHEMBL30560066 | 0.73 | HDAC3 (0.59) | SYKHDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL3503353 | 0.72 | JAK2 (0.63) | SYKIGF1RJAK2JAK3PKMYT1 | |
| SCHEMBL657421 | 0.71 | SYK (1.00) | SYKIGF1RJAK2JAK3PKMYT1 | |
| SCHEMBL12615134 | 0.71 | SYK (0.55) | SYKIGF1RTP53MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3733184-B1 | PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | ICAHN SCHOOL MED MOUNT SINAI (US) | 2023-08-30 | — | — | EP | claimed |