Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.74 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 11/20 | 0.62 |
| ▸ | RAB9A | P51151 | 11/20 | 0.62 |
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TPH1 | P17752 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17707864 | 0.93 | NR1H4 (0.61) | NR1H4S1PR1NPC1RAB9AMAPT | |
| SCHEMBL3061817 | 0.92 | NR1H4 (0.64) | NR1H4S1PR1NPC1RAB9AMAPT | |
| SCHEMBL3057378 | 0.88 | PPARD (0.58) | NR1H4S1PR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19968728 | 0.87 | S1PR1 (0.69) | NR1H4S1PR1NPC1RAB9AMAPT | |
| SCHEMBL6697420 | 0.86 | NR1H4 (1.00) | NR1H4S1PR1NPC1RAB9AMAPT | |
| SCHEMBL7291752 | 0.86 | NR1H4 (1.00) | NR1H4S1PR1NPC1RAB9AMAPT | |
| SCHEMBL26095786 | 0.84 | SMPD1 (0.63) | NR1H4S1PR1LMNASMPD1 | |
| SCHEMBL3061704 | 0.84 | S1PR1 (0.57) | NR1H4S1PR1NPC1RAB9AMAPT | |
| SCHEMBL7295337 | 0.82 | RAB9A (0.59) | NR1H4S1PR1NPC1RAB9AMAPT | |
| SCHEMBL3052115 | 0.82 | PPARD (0.53) | NR1H4S1PR1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045442-B2 | Antibacterial compounds and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2015-06-02 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2010-10-14 | — | — | US | disclosed |
| WO-2009082398-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009082398-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009041972-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009041972-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261673-A1 | ANTIBACTERIAL COMPOUNDS AND METHODS OF USING SAME | SPOUT1, MRPL21, NPEPPS | NR1H4 2734/4885S1PR1 3905/4885NPC1 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.