Sugi Predict

Sugi Predict / Compounds / SCHEMBL30567779

SCHEMBL30567779

SCHEMBL30567779

CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)[C@@H](C)O

nearest known ligand 0.64

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ CALCR P30988 4/20 0.64
▸ APLNR P35414 2/20 0.60
▸ MAPK8 P45983 1/20 0.57
▸ MAPK9 P45984 1/20 0.57
▸ MAPK10 P53779 1/20 0.57
▸ NPY2R P49146 8/20 0.56
▸ NPY4R P50391 8/20 0.56
▸ NPY5R Q15761 8/20 0.56
▸ NPY1R P25929 6/20 0.56
▸ GLP1R P43220 1/20 0.55
▸ CRHR1 P34998 1/20 0.55
▸ CRHR2 Q13324 1/20 0.55
▸ HCRTR1 O43613 1/20 0.54
▸ HCRTR2 O43614 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30231309 0.92 APLNR (0.62) CALCRAPLNRMAPK8MAPK9MAPK10
SCHEMBL29934240 0.91 APLNR (0.61) CALCRAPLNRMAPK8MAPK9MAPK10
SCHEMBL30607367 0.90 CALCR (0.60) CALCRAPLNRMAPK8MAPK9MAPK10
SCHEMBL31182808 0.89 CALCR (0.69) CALCRAPLNRNPY2RNPY4RNPY5R
SCHEMBL29389060 0.87 CALCR (0.72) CALCRAPLNRNPY2RNPY4RNPY5R
SCHEMBL30495635 0.87 NPY2R (0.66) CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL31182609 0.87 CALCR (0.71) CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL31182467 0.86 CALCR (0.73) CALCRAPLNRGLP1RCRHR1CRHR2
SCHEMBL31182442 0.86 CALCR (0.73) CALCRNPY2RNPY4RNPY5RNPY1R
SCHEMBL31182551 0.86 CALCR (0.68) CALCRAPLNRNPY2RNPY4RNPY5R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240277841-A2 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-08-22 — — US disclosed
US-20240024473-A1 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE PURDUE RESEARCH FOUNDATION (US) 2024-01-25 — — US disclosed
CN-116601290-A Human chimeric antigen receptor neutrophils, compositions, kits and methods of use 普渡研究基金会 2023-08-15 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240277841-A2 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE PBK, KIT, MYD88 CALCR 889/4885APLNR 128/4885MAPK8 1290/4885
US-20240024473-A1 HUMAN CHIMERIC ANTIGEN RECEPTOR NEUTROPHILS, COMPOSITIONS, KITS AND METHODS OF USE PBK, KIT, MYD88 CALCR 889/4885APLNR 128/4885MAPK8 1290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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