SCHEMBL30569684

SCHEMBL30569684

O=C1C(Cc2ccccc2Br)CNCC1Cc1ccccc1Br

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP27A1 Q02318 1/20 0.41
CYP24A1 Q07973 1/20 0.41
SLC6A2 P23975 2/20 0.37
MMP1 P03956 1/20 0.36
MMP2 P08253 1/20 0.36
MMP9 P14780 1/20 0.36
MMP12 P39900 1/20 0.36
TAAR1 Q96RJ0 3/20 0.36
IDO1 P14902 2/20 0.35
ATM Q13315 1/20 0.35
SLC6A4 P31645 1/20 0.34
P2RX7 Q99572 1/20 0.34
CYP2A13 Q16696 1/20 0.33
IKBKB O14920 1/20 0.33
DYRK2 Q92630 1/20 0.33
KDM1A O60341 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13719433 0.81 CMA1 (0.41) SLC6A2MMP1MMP2MMP9MMP12
Hydrochloric Acid SCHEMBL9296314 0.80 CYP27A1 (0.40) CYP27A1CYP24A1SLC6A2MMP1MMP2
SCHEMBL30569683 0.79 CMA1 (0.44) SLC6A2TAAR1IDO1SLC6A4
SCHEMBL30569687 0.78 PYCR1 (0.38) IDO1SLC6A4P2RX7
SCHEMBL30569682 0.78 NOS3 (0.38) SLC6A4P2RX7
SCHEMBL31518804 0.77 CYP27A1 (0.42) CYP27A1CYP24A1TAAR1ATMP2RX7
SCHEMBL30569685 0.71 POLB (0.40)
SCHEMBL29169537 0.71 PTGS1 (0.52) CYP27A1CYP24A1ATM
SCHEMBL30825588 0.71 PTGS1 (0.52) CYP27A1CYP24A1ATM
SCHEMBL9296486 0.71 PTGS1 (0.52) CYP27A1CYP24A1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115232068-B Compound and preparation method and application thereof 北京中医药大学 2023-09-08 CN disclosed