Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | RIOK2 | Q9BVS4 | 4/20 | 0.40 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30572725 | 0.91 | RET (0.49) | RETRIOK2NCF1CHRNB2CHRNA4 | |
| SCHEMBL19462890 | 0.73 | RET (0.45) | RETNCF1KITACVR1TGFBR1 | |
| SCHEMBL19459259 | 0.69 | LIPG (0.43) | RETNCF1KITACVR1TGFBR1 | |
| SCHEMBL19481688 | 0.69 | RET (0.54) | RET | |
| SCHEMBL19458933 | 0.69 | NCF1 (0.48) | RETNCF1HTR3AHTR6HTR2A | |
| SCHEMBL19482443 | 0.68 | RET (0.41) | RETNCF1KITACVR1TGFBR1 | |
| SCHEMBL30333672 | 0.68 | CYP1A2 (0.53) | RIOK2HTR2CCYP2C19PIK3CDPIK3CA | |
| SCHEMBL30333558 | 0.68 | CYP1A2 (0.64) | CYP2C19PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21679774 | 0.68 | KHK (0.43) | RETKITACVR1TGFBR1BMPR1B | |
| Hydrochloric Acid SCHEMBL19459005 | 0.68 | NCF1 (0.47) | RETNCF1HTR3AHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023165581-A1 | PYRIDINE DERIVATIVE AND USE THEREOF | 四川汇宇制药股份有限公司 | 2023-09-07 | — | — | WO | disclosed |