SCHEMBL30574149

SCHEMBL30574149

COP(=O)(OC)c1cccc(C(N)=O)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 12/20 0.54
PARP10 Q53GL7 5/20 0.44
PARP15 Q460N3 3/20 0.44
PARP14 Q460N5 2/20 0.44
PARP2 Q9UGN5 2/20 0.44
TNKS O95271 1/20 0.44
TNKS2 Q9H2K2 1/20 0.44
PLAU P00749 2/20 0.41
PLAT P00750 2/20 0.41
TSHR P16473 2/20 0.41
CYP1A2 P05177 1/20 0.41
POLB P06746 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAPT P10636 1/20 0.41
CYP2C19 P33261 1/20 0.41
RECQL P46063 1/20 0.41
BLM P54132 1/20 0.41
PMP22 Q01453 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14743718 0.83 TSHR (0.41) PARP1TSHRPOLB
SCHEMBL29503148 0.80 PARP1 (0.55) PARP1PARP10PARP15PARP14PARP2
SCHEMBL31019778 0.74 ALDH1A1 (0.45) CYP3A4RECQLTDP1CA1CA2
SCHEMBL31021028 0.72 PARP1 (0.73) PARP1PARP10PARP15PARP14PARP2
SCHEMBL36694 0.72 PARP1 (0.73) PARP1PARP10PARP15PARP14PARP2
SCHEMBL12230060 0.72 ACHE (0.44) TDP1L3MBTL1CA1CA2
SCHEMBL12230075 0.71 ACHE (0.40) CYP1A2POLBCYP3A4MAPTBLM
SCHEMBL283787 0.71 PARP1 (1.00) PARP1PARP10PARP15PARP14PARP2
SCHEMBL2490695 0.71 PARP1 (0.61) PARP1PLAUPLATTSHRPOLB
SCHEMBL12230058 0.71 ALDH1A1 (0.40) PARP1CYP1A2CYP3A4MAPTCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116715625-A Heteroaryl compounds as protein kinase inhibitors 福建海西新药创制股份有限公司 2023-09-08 CN disclosed